Tammy Dugas

    Tammy Dugas

    Professor, Department of Comparative Biomedical Sciences, LSU School of Veterinary Medicine

    LSU Superfund Research Program Oxidative Stress Core and Training Core leader.  

    Phone: (225) 578-7581

    Fax: (225) 578-9895

    Email: tammydugas@lsu.edu

    Website: http://www.lsu.edu/vetmed/cbs/people/faculty/dugas.php

    Research interests, expertise:

    • Mechanisms of cardiovascular injury induced by environmental toxicants and by pharmaceuticals
    • Mechanisms for cardioprotection by red wine polyphenols

    Recent publications:

    2015

    Jaligama, S., Chen, Z., Saravia, J., Yadev, N., Lomnicki, S., Dugas, T., Cormier, S.A. 2015. Exposure to Deepwater Horizon Crude Oil Burnoff Particulate Matter induces Pulmonary Inflammation and Alters Adaptive Immune Response. Environ. Sci. Technol. 49 (14):8769-8776. DOI: 10.1021/acs.est.5b01439. Publication Date (Web)L June 26, 2015. 

    2014

    Lee, G., Saravia, J., You, D., Shrestha, B., Jaligama, S., Hebert, V., Dugas. T., Cormier, S. 2014. Exposure to Combustion Generated Environmentally Persistent Free Radicals Enhances Severity of Influenza virus Infection. Part Fibre Toxicol. 11(1):57. Doi:10.1186/s12989-014-0057-1. [Epub ahead of print]

     

    Lomnicki, S., Gullett, B, Stöger,T., Kennedy, I., Diaz, J., Dugas, T.R., Varner, K., Carlin, D., Dellinger, B., and Cormier, S.A. 2013. Combustion By-Products and their Health Effects - Combustion Engineering and Global Health in the 21st Century: Issues and Challenges. International Journal of Toxicology. 33(1):3-13. Doi: 10.1177/1091581813519686. PMCID: PMC3944372 

    2013

    Kelley, M.A., Hebert, V.Y., Thibeaux, T.M., Orchard, M.A., Hasan, F., Cormier, S.A., Thevenot, P.T., Lomnicki, S.M., Varner,K.J., Dellinger, B, Latimer, B.M., Dugas, T.R. 2013. Model Combustion-Generated Particulate Matter Containing Persistent Free Radicals Redox Cycle to Produce Reactive Oxygen Species. Chem. Res. Toxicol. 26(12):1862-71. Doi: 10.1021/tx400227s.

    Thevenot, P., Saravia, J., Giammo, J., Happel, K.I., Dugas, T.R. and Cormier, S.A. 2013. Chronic Alcohol Induces M2 Polarization Enhancing Pulmonary Disease Caused by Exposure to Particulate Air Pollution. Alcoholism: Clinical and Experimental Research. 37(11): 1910-1919.Doi: 10.1111/acer.12184. PMCID: PMC3775861

    Thevenot P.T., Saravia J., Jin N, Giaimo J.D., Chustz R.E., Mahne S., Kelley M.A., Hebert V.Y., Dellinger B., Dugas T.R., Demayo F.J., Cormier S.A. 2013. Radical-containing ultrafine particulate matter initiates epithelial-to-mesenchymal transitions in airway epithelial cells. American Journal of Respiratory Cell and Molecular Biology. 48:188-197. Doi: 10.1165/rcmb.2012-0052OC. PMCID: PMC3604062

     

    Xue, S.Y., Hebert, V.Y., Hayes, D.M., Robinson, C.N., Glover, M., and Dugas, T.R. 2013. Nucleoside reverse transcriptase inhibitors induce a mitophagy-associated endothelial cytotoxicity that is reversed by coenzyme Q10 cotreatment. Toxicol Sci. 134(2):323-34.

    2012

    Khandelwal, A.R., Hebert, V.Y., Kleinedler, J.J., Rogers, L.K., Ullevig, S.L., Asmis, R., Shi, R., Dugas, T.R. 2012. Resveratrol and quercetin interact to inhibit neointimal hyperplasia in mice with a carotid injury. J Nutr. 142(2):1487-94.

    Kleinedler, J.J., Pjescic, I., Bullock, K.K., Khaliq, A., Foley, J.D., Dugas, T.R. 2012. Arterial pharmacokinectics of red wine polyphenols: implications for novel endovascular therapies targeting restenosis. J Pharm Sci. 101(5):1917-31.

    Kleinedler, J.J., Foley, J.D., Orchard, E.A., Dugas, T.R. 2012. Novel nanocomposite stent coating releasing resveratrol and quercetin reduces neointimal hyperplasia and promotes re-endothelialization. J Control Release. 159(1):27-33.

    2011

    Kelley, M.A., Thibeaux, T., Hebert, V., Cormier, S.A., Lomnicki, S., Dillinger, B., Dugas, T. 2011. Model Particulate Matter Containing Persistent Free Radicals Exhibit Reactive Oxygen Species Production. Free Radical Biology and Medicine. 51(1):S134. 

    Lord, K., Moll, D., Lindsey, J.K., Mahne, S., Raman, G., Dugas, T., Cormier, S., Troxlair, D., Lomnicki, S., Dellinger, B., & Varner, K. 2011. Environmentally persistent free radicals decrease cardiac function before and after ischemia/reperfusion injury in vivo. J Recept Signal Transduct Res. 31(2):157-67. Doi: 10.3109/10799893.2011.555767. PMCID:PMC3152960

    2010

    Khandelwal, A.R., Hebert,V.Y., Kleiner, H.E., and Dugas, T.R. 2010. Essential role of an ER-α dependent production of nitric oxide in modulating the anti-restenotic effects of resveratrol. Am. J. Physiol. Heart & Circ. Physiol. 299:H1451-1458.

    Jiang, B., Khandelwal, A.R., Rogers, L.K., Zavecz, J.H., Shi, W., Orr, A.W., and Dugas, T.R. 2010. Antiretrovirals induce endothelial dysfunction via an oxidant-dependent pathway and promote neointimal hyperplasia in C57BL/6 mice. Toxicol. Sci. 117:524-36.

     

    LSU