Luigi Marzilli
Distinguished Professor - Inorganic Chemistry -- William White Tison Professor
Bachelor's Degree(s): Brown University
PhD: Australian National University
PostDoc: University of Chicago
Area of Interest
Our research program is devoted to applying physical and synthetic chemical methods
to solving problems of biological and medical relevance. We explore the fundamental
chemistry of simpler compounds as well as large biomolecules with the goal of understanding
how metal species function in complex living systems. Toward this end, we rely heavily
on both synthetic chemistry and on physical techniques including 2D and dynamic NMR
and X-ray crystallography. We often undertake rate studies to determine the relationship
between structure and reactivity. Members of my group have diverse research opportunities
ranging from the exclusively synthetic to the exclusively quantitative. Transition
metal species are found in compounds essential for life-Co in vitamin B-12, Fe in
hemoglobin, and Zn, Cu, Mo, etc., in metalloenzymes. Metals have been incorporated
into drugs (Pt in anticancer agents, Au in antiarthritic agents) and in diagnostic
contrast agents (Tc, Gd) and also may function as pollutants (Cd, Hg, Pb and others).
Metallo Anticancer Drugs
We examine the binding of drugs to large molecular species, such as nucleic acids, using many physical and analytical techniques including 31P and1H NMR. My group also studies deoxyribonucleotides, which are synthetic pieces of the DNA double helix. Recently this work has provided new insights into the potential mode of action of Pt anticancer drugs, which are now the most widely used anticancer drugs in the world.
Metals in the Diagnosis of Disease
In a joint program with the Division of Nuclear Medicine, we are examining the synthesis of ligands and Tc-99m complexes with the aim of developing new diagnostic agents for studying kidney and heart function and also for imaging the brain. This program combines traditional synthetic chemistry with modern medical knowledge and instrumentation to solve important health problems.
Metals in Biology and as Probes of Biomolecular Structure
We prepare organocobalt compounds that are models for coenzyme B-12 and serve as probes
of biomolecule structures. For example, organocobalt porphyrins bind to DNA and reveal
features of the DNA structure through distinct spectral and reactivity patterns. Zinc
plays an important role in
biology and zinc is an important component of enzymes which repair DNA and catalyze
the hydrolysis of phosphodiester linkages.
Awards & Honors
Raymond F. Schinazi Faculty Fellow, International Exchange Programme of the University of Bath, UK
Guest Professor, University of Zurich
Distinguished Achievement Award from the International Precious Metals Institute
Honorary Member of the Italian Chemical Society
William White Tison Professor
Japanese Society for the Promotion of Science Sabbatical Fellowship
Bird Fellowship at the University of St. Andrews, Scotland
Japanese Society for the Promotion of Science Fellowship
Samuel Candler Dobbs Distinguished Professor, Emory University, 1986-2002
Fellow of the American Association for the Advancment of Science
Alexander von Humboldt US Senior Scientist Award 1983-1984
Charles H. Herty Award, Georgia Section of ACS, 2014
Southern Chemist Award, Memphis Section of ACS, 2014
Inaugural Bob Gawley Memorial Research Lecturer, 2014
Selected Publications
Malgorzata Lipowska, Jeffrey Klenc, Andrew T. Taylor, and Luigi G. Marzilli, "fac-99mTc/Re-tricarbonyl complexes with tridentate aminocarboxyphosphonate ligands: Suitability of the phosphonate group in chelate ligand design of new imaging agents," Inorg. Chim. Acta, 486, 529-537 (2019).
Kokila Ranasinghe, Patricia A. Marzilli, Svetlana Pakhomova, and Luigi G. Marzilli, "Linear Bidentate Ligands (L) with Two Terminal Pyridyl N-Donor Groups Forming Pt(II)Cl2 Complexes with Rare Eight-Membered Chelate Rings," Inorg. Chem., 57, 12756-12768 (2018).
Nerissa A. Lewis, Svetlana Pakhomova, Patricia A. Marzilli, and Luigi G. Marzilli, "Synthesis and Characterization of Pt(II) Complexes with Pyridyl Ligands: Elongated Octahedral Ion Pairs and Other Factors Influencing 1H NMR Spectra," Inorg. Chem., 56, 9781-9793 (2017).
Kokila Ranasinghe, Svetlana Pakhomova, Patricia A. Marzilli, and Luigi G. Marzilli, "A Very Rare Example of a Structurally Characterized 3'-GMP Metal Complex. NMR and Synthetic Assessment of Adducts Formed by Guanine Derivatives with [Pt(Ltri)Cl]Cl Complexes with an N,N',N" Tridentate Ligand (Ltri) Terminated by Imidazole Rings," Inorg. Chem., 56, 8462-8477 (2017).
Malgorzata Lipowska, Jeffrey Klenc, Nashwa Jarkas, Luigi G. Marzilli, and Andrew T. Taylor, "Monoanionic 99mTc- tricarbonyl-aminopolycarboxylate complexes with uncharged pendant groups: Radiosynthesis and evaluation as potential renal tubular tracers," Nuclear Medicine and Biology, 47, 48–55 (2017).
Chase Andrepont, Patricia A. Marzilli, Svetlana Pakhomova, and Luigi G. Marzilli, "Guanine Nucleobase Adducts Formed by a Monofunctional Complex: [Pt(N-(6-methyl-2-picolyl)-N-(2-picolyl)amine)Cl]Cl," J. Inorg. Biochem., 153, 219-230 (2015).
Jeffrey Klenc, Malgorzata Lipowska, Pramuditha L. Abhayawardhana, Andrew T. Taylor, and Luigi G. Marzilli, "Structure and Properties of fac-[ReI(CO)3(NTA)]2- (NTA3- = Tri-anion of Nitrilotriacetic Acid) and fac-[ReI(CO)3(L)]n- Analogs Useful for Assessing the Excellent Renal Clearance of the fac-[99mTcI(CO)3(NTA)]2- Diagnostic Renal Agent," Inorg. Chem., 54, 6281-6290 (2015).
Chase Andrepont, Svetlana Pakhomova, Patricia A. Marzilli, and Luigi G. Marzilli, "Unusual Example of Chelate Ring Opening upon Coordination of the 9-Ethylguanine Nucleobase to [Pt(di-(6-methyl-2-picolyl)amine)Cl]Cl," Inorg. Chem., 54, 4895-4908 (2015).
Nicola Margiotta, Emanuele Petruzzella, James A. Platts, Shaun Mutter, Robert J. Deeth, Rosa Ranaldo, Paride Papadia, Patricia A. Marzilli, Luigi G. Marzilli, James D. Hoeschele, and Giovanni Natile, "DNA Fragment Conformations in Adducts with Kiteplatin," Dalton Trans., 44, 3544-3556 (2015).
Pramuditha L. Abhayawardhana, Patricia A. Marzilli, Frank R. Fronczek, and Luigi G. Marzilli, "Complexes Possessing Rare “Tertiary” Sulfonamide Nitrogen-to-Metal Bonds of Normal Length: fac-[Re(CO)3(N(SO2R)dien)]PF6 Complexes with Hydrophilic Sulfonamide Ligands," Inorg. Chem., 53, 1144–1155 (2014).
Zakiya S. Wilson, Saundra Y. McGuire, Patrick A. Limbach, Michael P. Doyle, Luigi G. Marzilli, and Isiah M. Warner, "Diversifying Science, Technology, Engineering, and Mathematics (STEM): An Inquiry into Successful Approaches in Chemistry," J. Chem. Educ., 91, 1860-1866 (2014).
Nerissa A. Lewis, Patricia A. Marzilli, Frank R. Fronczek, and Luigi G. Marzilli, "Models for B12-Conjugated Radiopharmaceuticals. Cobaloxime Binding to New fac-[Re(CO)3(Me2bipyridine)(amidine)]BF4 Complexes Having an Exposed Pyridyl Nitrogen," Inorg. Chem., 53, 11096-11107 (2014).
Silvano Geremia, Lucio Randaccio, and Luigi G. Marzilli, "B12 Enzymes, Function and Small Molecules as Models," in Comprehensive Inorganic Chemistry II, Vol. 3, Bioinorganic Fundamentals and Applications: Metals in Natural Living Systems and Metals in Toxicology and Medicine, T. Hambley and V. Pecoraro, Eds., Elsevier: Amsterdam, pp. 423-453 (2013).
Theshini Perera, Pramuditha Abhayawardhana, Patricia A. Marzilli, Frank R. Fronczek, and Luigi G. Marzilli, "Formation of a Metal-to-Nitrogen Bond of Normal Length by a Neutral Sulfonamide Group within a Tridentate Ligand. A New Approach to Radiopharmaceutical Bioconjugation," Inorg. Chem., 52, 2412-2421 (2013).
Theshini Perera, Pramuditha Abhayawardhana, Frank R. Fronczek, Patricia A. Marzilli, and Luigi G. Marzilli, "Iminoether Complexes of the Type, fac-[Re(CO)3L(HNC(CH3)OCH3)]BF4 (L = Bipyridine or a Substituted Bipyridine): Synthesis and Properties," Eur. J. Inorg. Chem., 618-627 (2012).
Pramuditha Abhayawardhana, Patricia A. Marzilli, Theshini Perera, Frank R. Fronczek, and Luigi G. Marzilli, "New Monodentate Amidine Superbasic Ligands with a Single Configuration in fac-[Re(CO)3(5,5¢- or 6,6¢-Me2bipyridine)(amidine)]BF4 Complexes," Inorg. Chem., 51, 7271-7283 (2012).
Jeffrey Klenc, Malgorzata Lipowska, Luigi G. Marzilli, and Andrew T. Taylor, "Synthesis and Characterization of fac-Re(CO)3-aspartic-N-monoacetic Acid: Structural Analogue of a Potential Renal Tracer, fac-99mTc(CO)3(ASMA)," Eur. J. Inorg. Chem., 4334-4341 (2012).
Malgorzata Lipowska, Jeffrey Klenc, Luigi G. Marzilli, and Andrew T. Taylor, "Preclinical evaluation of 99mTc(CO)3-aspartic-N-monoacetic acid, 99mTc(CO)3(ASMA), a new renal radiotracer with pharmacokinetic properties comparable to 131I-OIH," J. Nucl. Med., 53, 1277-1283 (2012).
Chase Andrepont, Patricia A. Marzilli, and Luigi G. Marzilli, "Guanine Nucleobase Adducts Formed by [Pt(di-(2-picolyl)amine)Cl]Cl. Evidence That a Tridentate Ligand with Only in-Plane Bulk Can Slow Guanine Base Rotation," Inorg. Chem., 51, 11961-11970 (2012).
Jamil S. Saad, Patricia A. Marzilli, Francesco P. Intini, Giovanni Natile, and Luigi G. Marzilli, "Single-stranded Oligonucleotide Adducts Formed by Pt Complexes Favoring Left-handed Base Canting: Steric Effect of Flanking Residues and Relevance to DNA Adducts Formed by Pt Anticancer Drugs," Inorg. Chem., 50, 8608-8620 (2011).
Vidhi Maheshwari, Patricia A. Marzilli, and Luigi G. Marzilli, "Investigation Relevant to the Conformation of the 17-Membered Pt(d(GpG)) Macrocyclic Ring Formed by Pt Anticancer Drugs with DNA: Pt Complexes with a Goldilocks Carrier Ligand," Inorg. Chem., 50, 6626-6636 (2011).
Jamil S. Saad, Michele Benedetti, Giovanni Natile, and Luigi G. Marzilli, "NMR Studies of Models Having the Pt(d(GpG)) 17-Membered Macrocyclic Ring Formed in DNA by Platinum Anticancer Drugs: Pt Complexes with Bulky Chiral Diamine Ligands," Inorg. Chem., 50, 4559-4571 (2011).
Francesco P. Intini, Renzo Cini, Gabriella Tamasi, Michael B. Hursthouse, Luigi G.
Marzilli, and Giovanni Natile, X-ray Structural Characterization of the Bis-Guanine
Derivative of a Cisplatin Analogue Having Just One Proton on Each Coordinated Nitrogen
and a Head-to-Head Conformation: [Pt{(±)-N,N'-dimethylbutane-2,3-diamine}(9-ethyl-guanine)2]dinitrate," Inorg. Chem., 49, 7853-7860 (2010).
Theshini Perera, Frank R. Fronczek, Patricia A. Marzilli, and Luigi G. Marzilli, "Superbasic Amidine Monodentate Ligands in fac-[Re(CO)3(5,5'-Me2bipy)(Amidine)]BF4Complexes: Dependence of Amidine Configuration on the Remote Nitrogen Substituents," Inorg. Chem. 49, 7035-7045 (2010).
Jamil S. Saad, Michele Benedetti, Giovanni Natile,and Luigi G. Marzilli, "Basic Coordination Chemistry Relevant to DNA Adducts Formed by the Cisplatin Anticancer Drug. NMR Studies on Compounds with Sterically Crowded Chiral Ligands," Inorg. Chem., 49, 5573-5583 (2010).
Theshini Perera, Patricia A. Marzilli, Frank R. Fronczek, and Luigi G. Marzilli, "NH NMR Shifts of New Structurally Characterized fac-[Re(CO)3(polyamine)]n+Complexes Probed via Outer-Sphere Hydrogten-Bonding Interactions to Anions, Including the Paramagnetic [ReIVBr6]2- Anion," Inorg. Chem., 49, 5560-5572 (2010).
Andrew T. Taylor, Malgorzata Lipowska, and Luigi G. Marzilli, "99mTc(CO)3(NTA): A 99mTc Renal Tracer with Pharmacokinetic Properties in Normal Volunteers Comparable to Those of 131I-OIH, " J. Nucl. Med., 51, 391-396 (2010).
Malgorzata Lipowska, Haiyang He, Xiaolong Xu, Andrew T. Taylor, Patricia A. Marzilli, and Luigi G. Marzilli, "Multidentate Ligand Linkage Isomerism of fac-[Re(CO)3(polyaminocarboxylate)] Analogues of 99mTc Radiopharmaceuticals. Dependence on Solution pH," Inorg. Chem.,49, 3141-3151 (2010).
Theshini Perera, Patricia A. Marzilli, Frank R. Fronczek, and Luigi G. Marzilli, "Several Novel N-Donor Tridentate Ligands Formed in Chemical Studies of New fac-Re(CO)3Complexes Relevant to fac-99mTc(CO)3Radio-pharmaceuticals. Attack of a Terminal Amine on Coordinated Acetonitrile," Inorg. Chem., 49, 2123-2131 (2010).
Jamil S. Saad, Giovanni Natile,and Luigi G. Marzilli, "Origins of the Distortions in the Base-Pair Step Adjacent to Platinum Anticancer Drug-DNA Adducts. Fundamental NMR Solution Studies Utilizing Right-Handed Cross-link Models Having 5'- and 3'-Flanking Residues," J. Am. Chem. Soc., 131, 12314–12324 (2009).
Jamil S. Saad, Giovanni Natile, and Luigi G. Marzilli, "Origins of the Distortions in the Base Pair Step Adjacent to Platinum Anticancer Drug-DNAAdducts. Fundamental NMR Solution Studies Utilizing Right-Handed Crosslink Models Having 5'- and 3'-Flanking Residues," J. Am. Chem. Soc., in press (2009).
Janet Manono, Patricia A. Marzilli and Luigi G. Marzilli, "New Porphyrins Bearing Positively Charged Peripheral Groups Linked by a Sulfonamide Group to meso-Tetraphenylporphyrin: Interactions with Calf Thymus DNA," Inorg. Chem., 48, 5636-5647 (2009).
Janet Manono, Patricia A. Marzilli, Frank R. Fronczek and Luigi G. Marzilli, "New Porphyrins Bearing Pyridyl Peripheral Groups Linked by Secondary or Tertiary Sulfonamide Groups: Synthesis and Structural Characterization," Inorg. Chem., 48, 5626-5635 (2009).
Scott J. Moore, Patrizia Siega, Rene J. Lachicotte, Lucio Randaccio, Patricia A. Marzilli, and Luigi G. Marzilli, "Effects of Equatorial Ligand Bulk on the Orientation of Axial Ligands in Methyl Organocobalt B12 Models Assessed by X-Ray and NMR Methods," Inorg. Chim. Acta,362, 993-1002 (2009).
Malgorzata Lipowska, Luigi G. Marzilli, and Andrew T. Taylor, "99mTc(CO)3-Nitrilotriacetic Acid: A New Renal Radiopharmaceutical Showing in Rats Pharmacokinetic Properties Comparable to Those of 131I-OIH", J. Nucl. Med., 50, 454-460 (2009).
Anna Maria Christoforou, Patricia A. Marzilli, Frank R. Fronczek, and Luigi G. Marzilli, "fac-[Re(CO)3L] Complexes Containing Tridentate Monoanionic Ligands (L¯) Having a Terminal Amido and Two Amine Ligating Groups," J. Chem. Crystallogr., 38, 115-121 (2008).
Vidhi Maheshwari, Patricia A. Marzilli and Luigi G. Marzilli, "Neglected Bidentate sp2 N-Donor Carrier Ligands with Triazine Nitrogen Lone Pairs: Platinum Complexes Retromodeling Cisplatin Guanine Nucleobase Adducts," Inorg. Chem., 47, 9303–9313 (2008).
Anna Maria Christoforou, Patricia A. Marzilli, Frank R. Fronczek, and Luigi G. Marzilli, "fac-Re(CO)3L Complexes with N-CH2-CH2-X-CH2-CH2-N Tridentate Ligands. Synthetic, X-Ray Crystallographic, and NMR Spectroscopic Investigations," Inorg. Chem, 46, 11173-11182 (2007).
Kristie M. Adams, Patricia A. Marzilli, and Luigi G. Marzilli, "Reactions of fac-[Re(CO)3(H2O)3]+ with Nucleoside Diphosphates and Thiamine Diphosphate in Aqueous Solution Investigated by Multinuclear NMR Spectroscopy," Inorg. Chem., 46, 9172-9181 (2007).
Anna Maria Christoforou, Frank R. Fronczek, Patricia A. Marzilli and Luigi G. Marzilli, "fac-Re(CO)3L Complexes Containing Tridentate Monoanionic Ligands (L¯) with a Seldom-Studied Sulfonamido Group As One Terminal Ligating Group," Inorg. Chem., 46, 6942-6949 (2007).
H. He, M. Lipowska, X. Xu, A. T. Taylor, and L. G. Marzilli, "Rhenium Analogues of Promising Renal Imaging Agents with a {99mTc(CO)3}+Core Bound to Cysteine-derived Dipeptides, Including Lanthionine," Inorg. Chem., 46, 3385-3394 (2007).
Kristie M. Adams and Luigi G. Marzilli, "fac-[Re(CO)3(H2O)3]+ Nucleoside Monophosphate Adducts Investigated in Aqueous Solution by Multinuclear NMR Spectroscopy, " Inorg. Chem. 46, 4926-4936 (2007).
M. Benedetti, G. Tamasi, R. Cini, L. G. Marzilli, and G. Natile, “First Pure LHT Rotamer of a Complex with a cis-Metal(nucleotide)2 Unit. Acis-(Amine)2Pt(nucleotide)2 LHT Rotamer with Unique Molecular Structural Features,”Chem.-Eur. J., 13, 3131-3142 (2007).
Vidhi Maheshwari, Maria Carlone, Frank R. Fronczek, and Luigi G. Marzilli, "Ligand and Coordination-Plane Distortions in Pt(II) Complexes of Isomers of Dimethyl-2,2¢-bipyridine," Acta Crystallogr. Sect. B, Struc. Sci., B63, 603-611 (2007).
Haiyang He, Malgorzata Lipowska, Anna Maria Christoforou, Luigi G. Marzilli, and Andrew T. Taylor, "Evaluation of new potential99mTc(CO)3 renal imaging agents having carboxyl-rich thioether ligands and chemical characterization of Re(CO)3 analogues," Nucl. Med. Biol., 34, 709-716 (2007).
Andrei N. Vzorov, Jadranka Bozja, Dabney W. Dixon, Luigi G. Marzilli, and Richard W. Compans. "Parameters of inhibition of HIV-1 infection by small anionic microbicides," Antiviral Research, 73, 60-68 (2007).
Joseph J. Shiang, Allwyn G. Cole, Roseanne J. Sension, Kun Hang, Yuxiang Weng, Jenna S. Trommel, Luigi G. Marzilli, and Tianquan Lian, “Ultrafast Excited State Dynamics in Vitamin B12 and Related Cob(III)alamins," J. Am. Chem. Soc., 128, 801-808 (2006).
Vidhi Maheshwari, Debadeep Bhattacharyya, Frank R. Fronczek, Patricia A. Marzilli, and Luigi G. Marzilli, "Chemistry of HIV-1 Virucidal Pt Complexes Having Neglected Bidentate sp2 N-donor Carrier Ligands with Linked Triazine and Pyridine Rings. Synthesis, NMR Spectral Features, Structure, and Reaction with Guanosine," Inorg. Chem., 45, 7182-7190 (2006).
Anna Maria Christoforou, Patricia A. Marzilli, and Luigi G. Marzilli, "The Neglected Pt-N(sulfonamido) Bond in Pt Chemistry. New Fluorophore-Containing Pt(II) Complexes Useful for Assessing Pt(II) Interactions with Biomolecules," Inorg. Chem., 45, 6771-6781 (2006).
Patrizia Siega, Lucio Randaccio, Patricia A. Marzilli, and Luigi G. Marzilli, "Metal Coordination by Sterically Hindered Heterocyclic Ligands, Including 2-Vinylpyridine, Assessed by Investigation of Cobaloximes" Inorg. Chem., 45, 3359-3368 (2006).
Giovanni Natile and Luigi G. Marzilli, "Non-covalent interactions in adducts of platinum drugs with nucleobases in nucleotides and DNA as revealed by using chiral substrates," Coord. Chem Rev., 250, 1315-1331 (2006).
Malgorzata Lipowska, Haiyang He, Eugene Malveaux, Xiaolong Xu, Luigi G. Marzilli, and Andrew Taylor, “First Evaluation of a 99mTc Tricarbonyl Complex, 99mTc(CO)3(LAN), As a New Renal Radiopharmaceutical in Humans,” J. Nucl. Med., 47, 1032-1040 (2006).
M. Lipowska, H. He, X. Xu, E. Malveaux, A. T. Taylor, and L. G. Marzilli, "Rhenium and 99mTechnetium Complexes of Mercaptoacetylglycylglycylserine (Mag2-Ser), a Potential Alternative for 99mTcO(MAG3)," in Technetium, Rhenium, and Other Metals in Chemistry and Nuclear Medicine 7, U. Mazzi, Ed., SGEditoriali, Padova, 2006; p. 115-116.
L. G. Marzilli A. M. Christoforou, V. Maheshwari, K. M. Adams, F. R. Fronczek, and P. A. Marzilli, "Exploring the Chemistry of Neglected Ligands by Using Complexes with the Rhenium Tricarbonyl Core," in Technetium, Rhenium, and Other Metals in Chemistry and Nuclear Medicine 7, U. Mazzi, Ed., SGEditoriali, Padova, 2006; p. 3-8.
Vladimir Beljanski, Julie M. Villanueva, Paul W. Doetsch, Giovanni Natile, and Luigi G. Marzilli, "Marked Dependence on Carrier-Ligand Bulk but Not on Carrier-Ligand Chirality of the Duplex versus Single-Strand Forms of a DNA Oligonucleotide with a Series of G–Pt(II)–G Intrastrand Cross-Links Modeling Cisplatin-DNA Adducts," J. Am. Chem. Soc., 127, 15833-15842 (2005).
Andrei N. Vzorov, Debadeep Bhattacharyya, Luigi G. Marzilli, and Richard W. Compans, "Prevention of HIV-1 Infection by Platinum Triazines," Antiviral Research, 65, 57-67 (2005).
Manuela Trani, Francesco Cannito, Giovanni Natile, Patricia A. Marzilli, and Luigi G. Marzilli, "Slowly Exchanging cis-PtA2B2 Atropisomers with A2 = Chiral Diamine Ligands, and B = 5,6-Dimethylbenzimidazole," Eur. J. Inorg. Chem., 2826-2835 (2005).
Maria Carlone, Luigi G. Marzilli, and Giovanni Natile, "Platinum Complexes with Only One Purine Ligand (Guanine, Deoxyguanine, or Adenine) Flanked by Two cis-NH(CH3) Groups. Informative Models for Assessing the Interaction of Purine-C6 Substituents with cis-Amines," Eur. J. Inorg. Chem., 7, 1264-1273 (2005).
Michele Benedetti, Luigi G. Marzilli, and Giovanni Natile, "Rotamer Stability in cis-[Pt(diA)G2] Complexes (diA = Diamine Derivative and G = Guanine Derivative) Mediated by Carrier-Ligand Amine Stereochemistry As Revealed by CD Spectroscopy," Chem.-Eur. J., 11, 5302-5310 (2005).
Debadeep Bhattacharyya, Patricia A. Marzilli, and Luigi G. Marzilli, "Exploring the Universality of Unusual Conformations of the 17-Membered Pt(d(G*pG*)) Macrochelate Ring. Dependence of Conformer Formation on a Change in Bidentate Carrier Ligand from an sp3 to an sp2 Nitrogen Donor," Inorg. Chem., 44, 7644-7651 (2005).
Haiyang He, Malgorzata Lipowska, Xiaolong Xu, Andrew T. Taylor, Maria Carlone, and Luigi G. Marzilli, "Re(CO)3 Complexes Synthesized via an Improved Preparation of Aqueous fac-[Re(CO)3(H2O)3]+ As an Aid in Assessing 99mTc Imaging Agents. Structural Characterization and Solution Behavior of Complexes with Thioether-bearing Amino Acids As Tridentate Ligands," Inorg. Chem., 44, 5437-5446 (2005).
Malgorzata Lipowska, Renzo Cini, Gabriella Tamasi, Xiaolong Xu, Andrew Taylor, Jr., and Luigi G. Marzilli, "Complexes Having the fac-{M(CO)3}+ Core (M = Tc, Re) Useful in Radiopharmaceuticals. X-ray and NMR Structural Characterization and Density Functional Calculations of Species Containing Two sp3 N Donors and One sp3 O Donor," Inorg. Chem., 43, 7774-7783 (2004).
M. Carlone, Luigi G. Marzilli, and Giovanni Natile, "Platinum Complexes with NH Groups on the Carrier Ligand and with Only One Guanine or Hypoxanthine Derivative. Informative Models for Assessing Relative Nucleobase and Nucleotide Hydrogen-Bond Interactions with Amine Ligands in Solution," Inorg. Chem., 43, 584-592 (2004).
Vladimir Beljanski, Luigi G. Marzilli, and Paul W. Doetsch, "DNA Damage Processing Pathways Involved in the Eukaryotic Cellular Response to Anticancer DNA Crosslinking Drugs," Mol. Pharmacol., 65, 1496-1506 (2004).
Andrew Taylor, Malgorzata Lipowska, Lory Hansen, Eugene Malveaux, and Luigi G. Marzilli, "99mTc-MAEC Complexes: New Renal Radiopharmaceuticals Combining Characteristics of 99mTc-MAG3 and 99mTc-EC," J. Nucl. Med., 45, 885-891 (2004).
G. Garau, S. Geremia, L. G. Marzilli, G. Nardin, L. Randaccio, and G. Tauzher, "Crystal Chemistry and Binding of NO2, SCN, and SeCN to Co in Cobalamins," Acta Crystallogr B., 59, 51-59 (2003).
Gianpiero Colonna, Nicola G. Di Masi, Luigi G. Marzilli, and Giovanni Natile, "Ground-State Stability and Rotational Activation Parameters for Individual Rotamers of (R,S,S,R)-(N,N'-Dimethyl-2,3-diaminobutane)PtG2 Complexes (G = 9-EtG, 3'-GMP, and 5'-GMP)," Inorg. Chem., 42, 997-1005 (2003).
Andrei N. Vzorov, Luigi G. Marzilli, Richard W. Compans, and Dabney W. Dixon, "Prevention of HIV-1 Infection by Phthalocyanines,"Antiviral Research, 59, 99-109 (2003).
Michele Benedetti, Jamil S. Saad, Luigi G. Marzilli, and Giovanni Natile, "Chiral discrimination in the formation reaction and at equilibrium forN,N,N',N'-tetramethyl-1,2-diaminocyclohexane–PtG2 complexes," Dalton Trans., 872-879 (2003).
A. R. M. Chen-Collins, D. W. Dixon, A. N. Vzorov, L. G. Marzilli, and R. W. Compans, "Prevention of poxvirus infection by tetrapyrroles,"BMC Infectious Diseases 2003, 3:9. Full text from: http://www.biomedcentral.com/1471-2334/3/9
Jamil S. Saad, Tommaso Scarcia, Giovanni Natile, and Luigi G. Marzilli, "Factors Influencing Conformer Equilibria in Retro Models of Cisplatin–DNA Adducts As Revealed by Moderately Dynamic (N,N'-dimethyl-2,3-diaminobutane)PtG2 Retro Models (G = a Guanine Derivative)," Inorg. Chem., 41, 4923-4935 (2002).
Malgorzata Lipowska, Lory Hansen, Xiaolong Xu, Patricia A. Marzilli, Andrew Taylor, Jr., and Luigi G. Marzilli, "New N3S Donor Ligand Small Peptide Analogues of the N-Mercaptoacetyl-glycylglycylglycine Ligand in the Clinically Used Tc-99m Renal Imaging Agent: Evidence for Unusual Amide Oxygen Coordination by Two New Ligands," Inorg. Chem., 41, 3032-3041 (2002).
Jamil S. Saad, Tommaso Scarcia, Kazuo Shinozuka, Giovanni Natile, and Luigi G. Marzilli, "Modification of Second-Sphere Communication Leading to an Unusually High Abundance of the Head-to-Head Conformer of Cisplatin Cross-Link Retro Models," Inorg. Chem., 41, 546-557 (2002).
Sharon T. Sullivan, Jamil S. Saad, Francesco P. Fanizzi, and Luigi G. Marzilli, "Dramatic 5'-Residue Effect on Conformer Distribution of Short Oligonucleotide Retro Models of the Cisplatin–DNA Cross-Link. Implications for the Lippard and Cross-Link Distorted Base Pair Steps Present in Cisplatin-DNA Duplex Adducts," J. Am. Chem. Soc., 124, 1558-1559 (2002).
Enzo Alessio, Elisabetta Iengo, and Luigi G. Marzilli, "Metal-mediated Discrete Supramolecular Assemblies of Porphyrins," Supramolecular Chem., 14, 103-120 (2002).
M. Lipowska, L. Hansen, R. Cini, X. Xu, H. Choi, A. T. Taylor, Jr. and L. G. Marzilli, "Synthesis of New N2S2 Ligands and Re(V)O(N2S2) Analogues of 99mTc Renal Imaging Agents. Characterization by NMR Spectroscopy, Molecular Mechanics Calculations and X-ray Crystallography," Inorg. Chim. Acta, 339, 327-340 (2002).
A. N. Vzorov, D. W. Dixon, J. S. Trommel, L. G. Marzilli, and R. W. Compans, "Inactivation of Human Immunodeficiency Virus Type 1 by Porphyrins," Antimicrobial Agents and Chemotherapy, 46, 3917-3925 (2002).
Sharon T. Sullivan, Antonella Ciccarese, Francesco P. Fanizzi, and Luigi G. Marzilli, "A Rare Example of Three Abundant Conformers in One Retro Model of the Cisplatin-DNA d(GpG) Intrastrand Cross-link. Unambiguous Evidence That Guanine O6 to Carrier Amine Ligand Hydrogen Bonding Is Not Important. Possible Effect of the Lippard bp Step Adjacent to the Lesion on Carrier Ligand Hydrogen Bonding in DNA Adducts," J. Am. Chem. Soc., 123, 9345-9355 (2001).
Jenna S. Trommel, Kurt Warncke, and Luigi G. Marzilli, "Assessment of the Existence of Hyper-Long Axial Co(II)-N Bonds in Cobinamide B12 Models by Using Electron Paramagnetic Resonance Spectroscopy," J. Am. Chem. Soc., 123, 3358-3366 (2001).
A. Taylor, L. Hansen, and L. G. Marzilli, "Biodistribution and Renal Excretion of Isomers of the Cationic Tracer, Tc-99m Diaminocyclohexane (DACH)," Nucl. Med. Biol., 28, 299-302 (2001).
Jenna S. Trommel and Luigi G. Marzilli, "Synthesis and DNA Binding of Novel Water-Soluble Cationic Methylcobalt Porphyrins," Inorg. Chem., 40, 4374-4383 (2001).
Elisabetta Iengo, Romina Minatel, Barbara Milani, Luigi G. Marzilli, and Enzo Alessio, "Metal-mediated self-assembly of molecular squares of porphyrins rimmed with coordination compounds," Eur. J. Inorg. Chem., 3, 609-612 (2001).
S. T. Sullivan, A. Ciccarese, Francesco P. Fanizzi, and Luigi G. Marzilli, "Cisplatin-DNA Cross-link Retro Models with a Chirality-Neutral Carrier Ligand: Evidence for the Importance of 'Second-Sphere Communication'," Inorg. Chem., 40, 455-462 (2001).
Kevin M. Williams, Tommaso Scarcia, Giovanni Natile, and Luigi G. Marzilli, "Imprinting Structural Information from a GpG Ligand into the Configuration of a Chiral Diamine Ligand through Second-Sphere Communication in Platinum(II) Complexes," Inorg. Chem., 40, 445-454 (2001).
Luigi G. Marzilli, Jamil Saad, Zsuzsanna Kuklenyik, Kelly A. Keating, and Yinghai Xu, "Relationship of Solution and Protein-Bound Structures of DNA Duplexes with the Major Intrastrand Cross-Link Lesions Formed on Cisplatin Binding to DNA," J. Am. Chem. Soc., 123, 2764-2770 (2001).
Former Ph. D. Students
Theshini Perera, University of Sri Jayewardenepura
Vidhi Maheswari, Harvard Medical School
Kristie Adams, US Pharmacopeia
Anna Christoforou, National Science Foundation, Cyprus
Michael Summers, Howard Hughes Professor, University of Maryland
Jamil Saad, Asst. Prof. Department of Microbiology, Univ. of Alabama Birmingham
Srini Mukundan, Assoc. Prof., Harvard Medical School
Vladimir Beljanski, Vaccine and Gene Therapy Institute of Florida
Debadeep Bhattacharyya, Waters Corporation
James Strickland, Director of R&D, UST, USSTMLP, Nashville, TN
Scott Moore, Inspector General’s Office, NSF
Michael Reily, Bristol-Myers Squibb, (NJ)
Mengfen Lin, Wyeth Pharmaceuticals (PA)
Thomas Pagano, Abbott Labs (IL)
Marian Iwamoto, MD/PhD, Merck (NJ)
James Puckett, CIBA Geigy
Wallace Parker, EniChem, Milan, Italy
Julie Villanueva, Batelle
Alessandra Gerli, Nalco Chemicals, The Netherlands
Zsuzsanna Kuklenyik, Centers for Disease Control
Barbara Heyl, Assoc. Prof., Piedmont Virginia Community College
Suzette Polson, Kentucky State University
Kevin Williams,Western Kentucky University
Paul Toscano, Prof. of Chemistry, Dept. of Chemistry, SUNY Albany
Baltazar De Castro, Prof. of Chemistry, Univ. of Oporto, Portugal