Education

PhD, Tulane University, 2007

BS, Louisiana State University, 1999

Research Interest

Pneumonia is a common lung infection with millions of cases each year around the world. Neutrophils are an essential part of the innate immune response and among the first cells to be recruited in response to infection. Neutrophils phagocytize and kill microbes through the action of reactive oxygen species (ROS), reactive nitrogen species (RNS), and myeloperoxidase. The remaining extracellular bacteria are captured and destroyed by neutrophil extracellular traps (NETs). However, the immune response to lung pathogens can cause substantial tissue damage, increasing morbidity and mortality in pneumonia. Recently, a subset of neutrophils known as low-density neutrophils (LDNs) was described and has since been found to be associated with pro- and anti-inflammatory immune responses. Recent evidence suggests that CD11blow LDNs play an anti-inflammatory role in pneumonia and participate in the resolution of inflammation, while CD11bhigh LDNs are pro-inflammatory. We use in vitro studies and animal models to define the role of CD11blow LDNs in the regulation of the immune response during pneumonia. Investigations into the innate immune response and subsequent inflammatory lung damage are critical to lowering the morbidity and mortality from pneumonia.

Publications

Role of an anti-aging molecule in a toxic lifestyle: Relevance for alcohol effects on sepsis., Jeansonne, Duane; Jeyaseelan, Samithamby, 2021, Alcoholism, clinical and experimental research , Volume: 45, Number: 5, Pages: 912-915

Isolation, Transfection, and Culture of Primary Human Monocytes., Plaisance-Bonstaff, K; Faia, C; Wyczechowska, D; Jeansonne, Duane; Vittori, C; Peruzzi, F, 2019, Journal of visualized experiments : JoVE , Number: 154

A miRNA Signature for Cognitive Deficits and Alcohol Use Disorder in Persons Living with HIV/AIDS., Wyczechowska, D; Lin, H; LaPlante, A; Jeansonne, Duane; Lassak, A; Parsons, C; Molina, P; Peruzzi, F, 2017, Frontiers in molecular neuroscience , Volume: 10, Pages: 385

HIV-1-Tat Protein Inhibits SC35-mediated Tau Exon 10 Inclusion through Up-regulation of DYRK1A Kinase., Kadri, F; Pacifici, M; Wilk, A; Parker-Struckhoff, A; Del Valle, L; Hauser, K; Knapp, P; Parsons, C; Jeansonne, Duane; Lassak, A; Peruzzi, F, 2015, The Journal of biological chemistry , Volume: 290, Number: 52, Pages: 30931-46

Anti-tumoral effects of miR-3189-3p in glioblastoma., Jeansonne, Duane; DeLuca, M; Marrero, L; Lassak, A; Pacifici, M; Wyczechowska, D; Wilk, A; Reiss, K; Peruzzi, F, 2015, The Journal of biological chemistry , Volume: 290, Number: 13, Pages: 8067-80

TgMAPK1 is a Toxoplasma gondii MAP kinase that hijacks host MKK3 signals to regulate virulence and interferon-γ-mediated nitric oxide production., Brumlik, M; Pandeswara, S; Ludwig, S; Jeansonne, Duane; Lacey, M; Murthy, K; Daniel, B; Wang, R; Thibodeaux, S; Church, K; Hurez, V; Kious, M; Zhang, B; Alagbala, A; Xia, X; Curiel, T, 2013, Experimental parasitology , Volume: 134, Number: 3, Pages: 389-99

Cerebrospinal fluid miRNA profile in HIV-encephalitis., Pacifici, M; Delbue, S; Ferrante, P; Jeansonne, Duane; Kadri, F; Nelson, S; Velasco-Gonzalez, C; Zabaleta, J; Peruzzi, F, 2013, Journal of cellular physiology , Volume: 228, Number: 5, Pages: 1070-5

Differential Effects of MicroRNAs on Glioblastoma Growth and Migration., Jeansonne, Duane; Pacifici, M; Lassak, A; Reiss, K; Russo, G; Zabaleta, J; Peruzzi, F, 2013, Genes , Volume: 4, Number: 1, Pages: 46-64

A novel solubility-enhanced curcumin formulation showing stability and maintenance of anticancer activity., Zhang, F; Koh, G; Jeansonne, Duane; Hollingsworth, J; Russo, P; Vicente, G; Stout, Rhett; Liu, Z, 2011, Journal of pharmaceutical sciences , Volume: 100, Number: 7, Pages: 2778-89

Paclitaxel-induced apoptosis is blocked by camptothecin in human breast and pancreatic cancer cells., Jeansonne, Duane; Koh, G; Zhang, F; Kirk-Ballard, H; Wolff, L; Liu, D; Eilertsen, K; Liu, Z, 2011, Oncology reports , Volume: 25, Number: 5, Pages: 1473-80